Best copper peptide serum: What they are and how they work

Peptides have, in the last few years, become one of the most talked about ingredients in the anti-ageing skincare space.

The collagen-stimulating short-string amino acids are found naturally in the skin but become less effective with age, and skincare containing them is often discussed in the same context as Botox and retinol, praised for their ability to repair, hydrate, firm and tighten.

More specifically, copper peptides have been gaining popularity in serum form as a potent treatment. The combination of the aforementioned peptides with copper enzymes is designed to work at the deeper layers of the skin tissue to plump the complexion and smooth out the appearance of fine lines and wrinkles.

We reached out to Emma Wedgwood, Advanced Nurse Practitioner, to find out more.

“Copper peptide serums are skincare products formulated with copper peptides—small molecules of copper ions bonded to amino acids”, she explains. “These peptides support the skin’s natural healing and regeneration processes. They stimulate collagen and elastin production, helping improve skin firmness and elasticity and strengthening the skin barrier”.

Wedgwood continues, “Copper peptides act as powerful antioxidants, protecting the skin from environmental damage caused by pollution and UV exposure. They help reduce inflammation and support the skin’s repair mechanisms, making them especially beneficial for ageing or damaged skin”.

According to the expert, “Copper peptide serums can be highly effective, but their results often depend on your skin type, consistency of use, and the product’s formulation”.

She spotlights studies that reveal “copper peptides promote smoother, firmer skin, reduce fine lines and wrinkles, and enhance skin elasticity over time”. But cautions, “They aren’t an overnight solution. They should be part of a regular skincare routine to see noticeable results, as consistent use over weeks or months is usually needed. The quality of the product and the concentration of copper peptides play a significant role in determining how effective the serum will be”.

“Copper peptide serums are best applied to dry skin after cleansing and toning”, Wedgwood says. “You can use them in the morning, evening, or both, depending on your preference. Many people find they work best when applied at night, allowing the skin to fully benefit from their repair-boosting properties during its natural regeneration process. Simply apply a small amount to your face and neck and gently pat it until fully absorbed”.

When it comes to layering with the rest of your skincare routine, she notes “Copper peptides don’t pair well with strong acids (like AHAs or BHAs) or vitamin C in the same skincare routine, as these can reduce their effectiveness. To avoid this, alternate their use — apply copper peptides in the morning and vitamin C in the evening, for example. Always finish with a moisturiser to lock in hydration, and if using copper peptides during the day, apply SPF to protect your skin from sun damage”.

Shop the best copper peptide serums below